NCT03834168

The Diurnal Rhythm in Natriuretic Peptide Levels

The Diurnal Rhythm in Natriuretic Peptide Levels and Relationship With Nocturnal Blood Pressure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study to assess the diurnal rhythm in natriuretic peptide levels and its temporal relationship with nocturnal blood pressure in obese and African-American individuals as compared with lean and white individuals.

Detailed description

Obese and African-American individuals are at greater risk for cardiovascular morbidity and mortality than lean and white individuals. One of the key reasons for this health disparity is a higher risk of hypertension among obese and African-American individuals. The reasons for why these disparities develop are not well understood. Natriuretic peptides are hormones produced by the heart and have a wide range of favorable cardiovascular effects such as natriuresis (sodium excretion), vasodilation, and direct inhibition of the renin-angiotensin-aldosterone system. Human studies showed the existence of 24-hour (diurnal) variations in the circulating natriuretic peptide levels. Prior work from the investigators and others demonstrated that individuals with genetically-determined lower circulating natriuretic peptides levels have higher blood pressure and greater risk of hypertension. Further, the investigators have shown that obesity and African-American race are associated with lower natriuretic peptide levels, suggesting that relatively low natriuretic peptide levels may be a biologic determinant contributing to health disparities. Obese and African-American individuals have a greater prevalence of nocturnal hypertension \[nighttime blood pressure \>120/80 mmHg\], which is an independent risk factor for cardiovascular events. The underlying reasons for 24-hour variations in blood pressure are unknown. The investigators hypothesize that loss of the natural 24-hour rhythm of natriuretic peptide levels plays a role in the development of nocturnal hypertension in obese and African-American individuals. The aims of this study are: 1. to examine whether there is a presence of a 24-hour rhythm in natriuretic peptide levels among normotensive obese and African-American individuals and whether there is a difference in the rhythmicity of natriuretic peptide levels between obese and lean as well as in African-Americans and whites; 2. to examine whether there is an existence of a relationship between 24-hour variability of natriuretic peptide levels and 24-hour patterns of blood pressure and whether this relationship of rhythmicity of natriuretic peptide levels and nocturnal blood pressure differed in obese and lean individuals and by race.

Conditions

• Natriuretic Peptides
• Obesity
• Nocturnal Blood Pressure

Interventions

Type	Name	Description
OTHER	standardized Study Diet	Standardized diet consisted with eucaloric meals with 4.5 gm of sodium per day for 5 days.

Timeline

• Start date: 2019-04-01
• Primary completion: 2020-02-29
• Completion: 2021-03-31
• First posted: 2019-02-07
• Last updated: 2024-02-05
• Results posted: 2021-08-31

Locations

1 site across 1 country: United States