NCT03833869

Assisted Hatching in Frozen Blastocysts

The Effect of Assisted Hatching on Implantation Rate in Frozen Blastocyst Transfer - a Prospective Randomized Controlled Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 84 (estimated)
• Sponsor: Wolfson Medical Center · Other Government
• Sex: Female
• Age: 18 Years – 39 Years
• Healthy volunteers: Accepted

Summary

The current study aims to assess the effect of assisted hatching on the implantation rate of frozen blastocytes.

Detailed description

The Zona Pellucida protects the ovum from the penetration of multiple sperm, and from mechanical and physiological damage until the fertilized ovum reaches the uterus. Subsequently, spontaneous hatching occurs, and enables the embryo to attach to the endometrium. The technique of assisted hatching was originally investigated as a means to improve implantation in cases of zona hardening, and is commonly performed in 3-day embryos. In the current study, the investigators aim to investigate the effect of assisted hatching on 5-day frozen embryos.

Conditions

• ART

Interventions

Type	Name	Description
PROCEDURE	Assisted hatching	Controlled hatching of the zona pellucida in the laboratory prior to embryo transfer

Timeline

• Start date: 2019-03-01
• Primary completion: 2020-03-01
• Completion: 2020-03-01
• First posted: 2019-02-07
• Last updated: 2019-06-11

Locations

1 site across 1 country: Israel