NCT03832439

Probiotic Supplementation on Weight Loss

The Effect of Probiotic Supplementation on Weight Loss, and Its Association With the Gut Microbiome After Bariatric Surgery.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The investigators are trying to better understand how bariatric surgery leads to weight loss, and the role of bacteria that live in the gut in making this happen.

Detailed description

The investigators are interested in seeing how a probiotic, which is a dietary supplement containing large amounts of 'good' bacteria, can influence the make-up of the gut bacterial population and what effect it has on weight loss and loss of fat. Before undergoing weight loss surgery (sleeve gastrectomy or roux-en-y gastric bypass), study participants will be asked to provide a stool sample to assess the make-up of their gut bacterial population. They will also undergo a limited CT scan of the abdomen and DEXA (Xray) to help assess the amount of fat present inside the body. After undergoing weight loss surgery (sleeve gastrectomy or roux-en-y gastric bypass), study participants will be given either a probiotic supplement or dummy pill (placebo) for 3 months, in addition to all usual care that occurs after surgery. The CT scan, DEXA scan and stool sample will be repeated at the end of the 3 month period and analyzed for changes.

Conditions

• Bariatric Surgery Candidate

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic	Lactobacillus rhamnosus GG 10 billion cells and microcrystalline cellulose
DIETARY_SUPPLEMENT	microcrystalline cellulose	Placebo

Timeline

• Start date: 2019-01-17
• Primary completion: 2021-04-28
• Completion: 2021-04-28
• First posted: 2019-02-06
• Last updated: 2022-02-21

Locations

1 site across 1 country: United States