NCT03831542

Effect of Follicular Flushing in Patients With Mono-follicular Growth Undergoing In Vitro Fertilization

Follicular Flushing in Patients With Mono-follicular Growth

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 71 (actual)
• Sponsor: Centrum Clinic IVF Center · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Retrieval of an oocyte from a follicle relies on the release of the cumulus-oocyte-complex (COC) from the follicular wall into the lumen, thereby allowing aspiration by a needle. Flushing the follicle with multiple aspirations from the same follicle is used as a means to increase the ratio of COC per aspirated follicle. Data showed that follicular flushing is not superior to direct aspiration either in normally responding patients or in poor responders undergoing in vitro fertilization (IVF). There is no data in the literature regarding the issue in patients with mono-follicular growth. Direct aspiration or repeatedly flushing the follicle for those with a single follicle will be investigated.

Detailed description

Oocyte retrieval procedure This study aims to evaluate the effect of follicular flushing during oocyte retrieval procedure in patients with only one follicle. Double lumen needle will be used and direct follicular aspiration without flushing will be performed for all patients. If an oocyte will be obtained, the patient will be assigned to group A. If not, at least 1 course of follicular flushing will be used until retrieval of an oocyte and the patient will be assigned to group B.

Conditions

• Invitro Fertilization
• Diminished Ovarian Reserve
• Oocyte

Interventions

Type	Name	Description
BEHAVIORAL	direct follicular aspiration	direct follicular aspiration
BEHAVIORAL	follicular flushing	follicular flushing

Timeline

• Start date: 2019-02-19
• Primary completion: 2019-05-05
• Completion: 2019-05-06
• First posted: 2019-02-06
• Last updated: 2019-05-07

Locations

1 site across 1 country: Turkey (Türkiye)