NCT03830814

The Effects of Sacubitril/Valsartan on the Heart Functions

What Are the Effects of Sacubitril/Valsartan on the Heart Functions? Can It Increase the Ejection Fraction?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: The Young Investigator Group of Cardiovascular Research · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Background: Sacubitril/valsartan, has been found to be more beneficial than enalapril for reducing the incidences of sudden cardiac death, death from worsening heart failure (HF), and hospitalization. However, there is no prospective echocardiographic data describing the effects of sacubitril/valsartan on the heart functions and left ventricular (LV) reverse remodeling. Therefore, the aim of our study was to evaluate the effects of sacubitril/valsartan on the LV functions using two dimensional (2D), three dimensional (3D) echocardiography and the 3D strain parameters. Methods: In 100 patients with HF with reduced ejection fraction (HRrEF) who have indications for the use of sacubitril/valsartan as recommended by recent guidelines were prospectively enrolled. The basal 2D and 3D echocardiographic parameters were compared to those obtained 3 months after starting the sacubitril/valsartan treatment.

Conditions

• Drug Effect

Interventions

Type	Name	Description
PROCEDURE	Echocardiography	Basal two dimensional and three dimensional echocardiographic parameters were compared to those obtained 3 months after starting the sacubitril/valsartan treatment

Timeline

• Start date: 2017-01-01
• Primary completion: 2018-07-31
• Completion: 2018-07-31
• First posted: 2019-02-05
• Last updated: 2019-02-05