NCT03828786

Uterine Scratching in Intra-Uterine Insemination

The Impact of Uterine Scratching Prior to Intra-Uterine Insemination in Unexplained Infertility, a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 394 (actual)
• Sponsor: Clinique Ovo · Industry
• Sex: Female
• Age: 18 Years – 41 Years
• Healthy volunteers: Accepted

Summary

This study will evaluate the potential benefits of uterine injury during the follicular phase of an intra-uterine insemination cycle on the rate of ongoing pregnancy during the first trimester ultrasound.

Detailed description

Infertility is defined as the absence of conception after a year of unprotected intercourse. In 10 to 30 % of patients, the cause of the infertility is unknown. An emerging practice in unexplained infertility has been to cause a uterine trauma prior to treatment. This is done by doing a small endometrial scratch with a pipelle. This intervention has been study in IVF and has been shown beneficial. Theoretically, the uterine scratching could increase the immune response and the vascularization of the endometrium which could help in embryo implantation. However, there is very few data concerning scratching in intrauterine insemination. The studies are mostly small studies and the results are often contradictory. In this randomized controlled trial, the investigators will evaluate the effect of uterine scratching during the follicular phase of an insemination cycle on the pregnancy rate of a large cohort of unexplained infertile couples.

Conditions

• Infertility
• Unexplained Infertility

Interventions

Type	Name	Description
PROCEDURE	Endometrial scratching	Endometrial Biopsy by aspiration with a pipelle

Timeline

• Start date: 2018-07-15
• Primary completion: 2023-03-31
• Completion: 2024-03-30
• First posted: 2019-02-04
• Last updated: 2025-03-20

Locations

1 site across 1 country: Canada