NCT03828032

Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients.

Alternations of Multi-parameters Including Hemodynamic Concentration and Water Levels During Dehydration Therapy on Brain Edema Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Ting Li · Unknown
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline. The investigators used a self-made near infrared spectroscopy (NIRS) instrument to monitor the physiological changes noninvasively including oxyhemoglobin (\[HbO2\]), deoxy-hemoglobin (\[Hb\]), the derived change in blood volume (\[tHb\]) and water concentration on the forehead of brain edema patients.

Detailed description

Cerebral edema, as an acute head injury along with high intracranial pressure, has been of great interest over decades in clinical neurosurgery research. Dehydration therapy is a common clinical method to decrease intracranial pressure. This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline. The investigators used a self-made near infrared spectroscopy (NIRS) instrument to monitor the physiological changes noninvasively including oxyhemoglobin (\[HbO2\]), deoxy-hemoglobin (\[Hb\]), the derived change in blood volume (\[tHb\]) and water concentration on the forehead of brain edema patients. Then the investigators compared the changes process of multiple physiological parameters during different dehydration therapies.

Conditions

• Hemodynamic Instability
• Water on the Brain
• Intracranial Pressure Increase

Interventions

Type	Name	Description
PROCEDURE	Mannitol injection	Standard mannitol injection to decrease intracranial pressure of patients
PROCEDURE	Hypertonic saline injection	Standard Hypertonic saline injection to decrease intracranial pressure of patients

Timeline

• Start date: 2019-09-01
• Primary completion: 2019-11-01
• Completion: 2019-12-11
• First posted: 2019-02-04
• Last updated: 2019-07-24