NCT03826745

The CHYMASE Angiotensin-(1-12) Axis in Cardiovascular Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 75 (estimated)
• Sponsor: Trinity Hypertension & Metabolic Research Institute · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

Study is to evaluate the Chymase Angiotensin-(1-12) in cardiovascular disease

Detailed description

Study is to determine the presence of the human sequence on Ang-(1-12) in the plasma of normal male and female normotensive, hypertensive and/or resistant hypertensive subjects. To measure concentrations of Ang-(1-12) in either serum or spot urine collections from male and female normal, hypertensive and/or resistant hypertensive subjects. To assess whether chymase activity can be detected in human serum and urine using the radiolabeled amino acid sequence of 1251-Ang-(1-12)

Conditions

• Cardiovascular Disease

Interventions

Type	Name	Description
OTHER	Plasma/Urine	Plasma of normal male and female normotensive, hypertensive, and/or resistant hypertensive subjects.

Timeline

• Start date: 2019-02-11
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2019-02-01
• Last updated: 2019-09-12

Locations

1 site across 1 country: United States