NCT03826147

Nitrite-boosting Therapy for Improving Physiological Function in Patients With Chronic Kidney Disease

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 92 (estimated)
• Sponsor: University of Colorado, Boulder · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Nitric oxide (NO) is an essential molecule in the body that is decreased in patients with chronic kidney disease (CKD), leading to reductions in vascular, movement ("motor") and cognitive functions. This study will determine if daily oral supplementation (3 months) with a supplement that increases NO in the body, i.e., nitrate-rich beetroot juice, improves vascular, motor and cognitive function in patients with CKD; this study will also provide insight into the biological reasons (mechanisms) by which supplementation with nitrate-rich beetroot juice improves vascular function in these patients. Overall, this research will provide scientific evidence supporting the use of nitrate-rich beetroot juice for preserving physiological function and preventing co-morbid clinical conditions and disability in CKD.

Conditions

• Chronic Kidney Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Nitrate-rich beetroot juice	Daily supplementation with \~100 kcal of nitrate-rich beetroot juice containing 400 mg of dietary nitrate (James White Drinks, UK).
DIETARY_SUPPLEMENT	Nitrate-depleted beetroot juice	Daily supplementation with \~100 kcal of nitrate-depleted beetroot juice (James White Drinks, UK).

Timeline

• Start date: 2019-05-01
• Primary completion: 2026-07-01
• Completion: 2026-08-01
• First posted: 2019-02-01
• Last updated: 2026-03-31

Locations

1 site across 1 country: United States