Trials / Completed
CompletedNCT03826004
Clemastine in Cardiovascular Surgery
Effect of Histamine H1 Receptor Antagonist Clemastine in Cardiovascular Surgery With Cardiopulmonary Bypass: A Pilot Study
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 100 (actual)
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
In this study, a prospective, randomized, double-blind pilot trial designed to evaluate the effect of histamine H1 receptor antagonist clemastine on perioperative anaphylaxis in cardiovascular surgery with cardiopulmonary bypass, especially for the efficacy and safety on reducing heparin and protamine associated anaphylaxis.
Detailed description
In this study, a prospective, randomized, double-blind pilot trial designed to evaluate the effect of histamine H1 receptor antagonist clemastine on perioperative anaphylaxis in cardiovascular surgery with cardiopulmonary bypass, especially for the efficacy and safety on reducing heparin and protamine associated anaphylaxis.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Clemastine | Clemastine fumarate 2mg/2ml intramuscular injection is administrated into the gluteus maximus muscle |
| DRUG | Saline Solution | Saline solution 2ml intramuscular injection is administrated into the gluteus maximus muscle |
Timeline
- Start date
- 2019-02-20
- Primary completion
- 2019-07-31
- Completion
- 2020-01-10
- First posted
- 2019-02-01
- Last updated
- 2020-01-13
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03826004. Inclusion in this directory is not an endorsement.