NCT03825276

Effect of Mango on Gut Microbiota and Metabolic Health

Metabolic Adaptations and Role of Nutritionally-Mediated Gut Microbiota Changes Following Mango Consumption in Overweight Men and Women : The MANGO Pilot Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. Polyphenols accumulate in the gut where they can positively modulate the microbiota. As gut microbiota may have a strong influence on cardiometabolic health, we hypothesize that mango consumption improves metabolic profile in overweight or obese individuals through beneficial changes in gut microbiota. The study of metagenomics, transcriptomics and metabolomics will be used to validate this hypothesis.

Conditions

• Gut Microbiota
• Metabolic Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Mango consumption	Daily consumption of 280 g of frozen mangos during 8 weeks. The daily dose in equivalent to a 2-cups serving.

Timeline

• Start date: 2019-01-15
• Primary completion: 2019-12-20
• Completion: 2022-12-01
• First posted: 2019-01-31
• Last updated: 2021-07-07

Locations

1 site across 1 country: Canada