NCT03822195

Lectine Pathway in Unstable Carotid Plaque

Evaluation of Lectine Pathway in Assessment of Unstable Carotid Plaque

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible correlations with clinical neurologic features.

Detailed description

In addition to the known hemodynamic criteria, instable carotid plaques can be responsible for brain ischemia, therefore is paramount to identify preoperatively possible markers of plaque instability. The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible correlations with clinical neurologic features. Study population will include 40 patients with internal carotid artery stenosis \>=70% (assessed by echocolordoppler), symptomatic or asymptomatic, surgically treated by endoarterectomy. Removed plaques will be evaluated by histologic exam and immunofluorescence for ficolins 1-2-3 and Mannose Binding Lectin (MBL). Plasma samples will be used for ELISA test of lectin pathway complement activation.

Conditions

• Carotid Artery Plaque
• Mannose-Binding Lectin Complement Pathway

Interventions

Type	Name	Description
PROCEDURE	Carotid endoarterectomy	Surgical removal of carotid bifurcation plaque and arterial repair (direct suture or patch)

Timeline

• Start date: 2019-04-01
• Primary completion: 2021-01-31
• Completion: 2021-02-28
• First posted: 2019-01-30
• Last updated: 2020-07-24