NCT03821467

Reproducibility of Dual Beam Doppler Fourier-domain Optical Coherence Tomography in Healthy Subjects

Short- and Long-term Reproducibility of Dual Beam Doppler Fourier-domain Optical Coherence Tomography Measurements in Healthy Subjects - a Pilot Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Dual beam Doppler Fourier-domain Optical coherence tomography (DOCT) is a noninvasive technique to quantify total retinal blood flow. To enable further development of this technique it is essential to assess short- and long-term reproducibility of DOCT blood flow measurements.

Detailed description

In the present study, total retinal blood flow will be measured with DOCT at multiple time points to gain information of short- and long-term reproducibility. In addition, provocation with flickering light will be performed, which is known to lead to vasodilatation and an increase in retinal blood flow in healthy subjects. Vessel diameters will also be measured using the Dynamic Vessel Analyzer (DVA).

Conditions

• Ocular Blood Flow

Interventions

Type	Name	Description
DEVICE	Dual beam Doppler Fourier-domain OCT (DOCT)	Retinal blood flow will be assessed using DOCT.
DEVICE	Dynamic Vessel Analyzer (DVA)	Retinal vessel diameters and oxygen saturation will be measured with the DVA device.
DEVICE	Optical coherence tomography (OCT)	Retinal morphology will be imaged using OCT.

Timeline

• Start date: 2018-11-19
• Primary completion: 2025-12-12
• Completion: 2025-12-12
• First posted: 2019-01-29
• Last updated: 2025-05-16

Locations

1 site across 1 country: Austria