Trials / Completed
CompletedNCT03819400
Evaluation of Kidney Graft's Fibrosis With Real Time Shear-wave Elastography
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 45 (actual)
- Sponsor
- University Hospital, Tours · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Kidney graft's fibrosis is correlated with prognostic of kidney's graft, wathever the initial etiology. Actually, that evaluation is based on histologic score of Banff FI/AT (0 to III). It is obtained thanks to punction-biopsy, which is invasive and can lead complications. This exam is systematic on M3 of the transplantation. Tissue's fibrosis is a proliferation of extracellular matrix, leading to an increase of fibrosed tissue rigidity. Elastography is an ultrasound technique allowing evaluation of tissues' rigidity. The purpose is the validation of elastograhpy, innovative and non -invasive technique, and more specifically Shear Wave Elastography (SWE). For this, strain ratio (SR) could improve intra-operator variability and estimate fibrosis' degree of kidney's graft.
Detailed description
Kidney graft's fibrosis is correlated with prognostic of kidney's graft, wathever the initial etiology. Actually, that evaluation is based on histologic score of Banff FI/AT (0 to III). It is obtained thanks to punction-biopsy, which is invasive and can lead complications. This exam is systematic on M3 of the transplantation. Tissue's fibrosis is a proliferation of extracellular matrix, leading to an increase of fibrosed tissue rigidity. Elastography is an ultrasound technique allowing evaluation of tissues' rigidity. The purpose is the validation of elastograhpy, innovative and non -invasive technique, and more specifically Shear Wave Elastography (SWE). For this, strain ratio (SR) could improve intra-operator variability and estimate fibrosis' degree of kidney's graft.
Conditions
Timeline
- Start date
- 2019-03-29
- Primary completion
- 2022-05-16
- Completion
- 2022-05-16
- First posted
- 2019-01-28
- Last updated
- 2024-04-23
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT03819400. Inclusion in this directory is not an endorsement.