NCT03818100

Neo-RT: A Study Investigating Whether Changing the Sequence of Treatments (Starting Radiotherapy Followed by Hormone Therapy Before Surgery) is Feasible

Neo-RT: Pre-operative Breast Intensity Modulated Radiotherapy in Patients Receiving Neo-adjuvant Hormonal Treatment for Breast Cancer - a Feasibility Study.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 43 (estimated)
• Sponsor: CCTU- Cancer Theme · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Four in 10 women diagnosed with breast cancer undergo mastectomy with or without breast reconstruction and less than half are satisfied with how they look unclothed. Breast conservation (removing the area with the lump only) can offer less extensive surgery and improved breast appearance, which can therefore increase well-being. Intensity-modulated radiotherapy (IMRT) closely shapes the radiation beam to the cancer and is currently given after breast surgery. A new combination of IMRT followed by hormone treatment given before surgery, may increase the possibility of breast conservation.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
RADIATION	Intensity modulated radiotherapy (IMRT)	Simultaneous integrated boost technique using IMRT: 48 Gray (Gy) and 40 Gy will treat tumour and breast tissue respectively, in 15 fractions over 3 weeks.
DRUG	Endocrine therapy	Endocrine therapy will commence following completion of radiotherapy, and will continue for 20 weeks.
PROCEDURE	Breast conserving surgery	Surgery carried out using local protocol following completion of endocrine therapy.

Timeline

• Start date: 2018-03-26
• Primary completion: 2022-04-30
• Completion: 2022-12-31
• First posted: 2019-01-28
• Last updated: 2021-07-27

Locations

1 site across 1 country: United Kingdom