NCT03817749

Ketone Supplementation, Glucose Control, and Cardiovascular Function

The Effects of Exogenous Ketone Supplementation on Cardiovascular Function and Glucose Control

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 30 Years – 69 Years
• Healthy volunteers: Not accepted

Summary

Post-prandial hyperglycemic excursions induce a cascade of deleterious effects on the body, including increased inflammation, production of reactive oxygen species, and impaired cardiovascular function. Ingestion of an exogenous oral ketone supplement blunts hyperglycemia in response to an oral glucose tolerance test. Accordingly, it is hypothesized that exogenous ketone supplement ingestion prior to a meal could be an effective strategy for blunting postprandial hyperglycemia. Therefore, the purpose of this study is to investigate the effect of short-term (14-days) pre-meal exogenous ketone supplementation on glucose control, cardiovascular function, inflammation, and oxidative stress in individuals at an elevated risk of type 2 diabetes.

Conditions

• Hyperglycemia, Postprandial
• Overweight and Obesity
• Diabetes Mellitus Risk

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Exogenous ketone monoester	Participants will consume 20g of the oral ketone monoester supplement 15 minutes prior to each meal of the day for 14 days. All meals will be provided throughout the 14-day supplementation period.

Timeline

• Start date: 2019-02-06
• Primary completion: 2020-03-01
• Completion: 2020-12-31
• First posted: 2019-01-25
• Last updated: 2021-04-28

Locations

1 site across 1 country: Canada