NCT03816813

Assessement of Hepcidin in Saliva in Human Volunteers

Detection of Hepcidin in Saliva and Its Utility as a Diagnostic Marker for Iron Deficiency

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 90 (actual)
• Sponsor: Swiss Federal Institute of Technology · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: —

Summary

Iron deficiency with or without anemia is considered the most widespread nutritional deficiency in the world. To diagnose iron deficiency anemia (hemoglobin and ferritin measurement), a venous blood sample is necessary. Whole saliva is a potentially attractive fluid for disease biomarker discovery and diagnostic efforts, because it is readily available from most individuals, can be easily collected and the collection procedure is non-invasive. The iron storage protein ferritin is too big, to be secreted into saliva. However, the main iron regulatory protein hepcidin is a very small protein and there is some evidence for hepcidin detection in saliva. The production of serum hepcidin positively correlates with serum ferritin, thereby reflecting patient's iron status. Whether hepcidin is detectable in saliva and whether saliva hepcidin correlates with serum hepcidin with current assays, needs to be tested.

Conditions

• Hepcidin, Saliva

Interventions

Type	Name	Description
OTHER	blood and saliva sampling	blood and saliva sampling

Timeline

• Start date: 2019-02-04
• Primary completion: 2019-02-07
• Completion: 2019-02-07
• First posted: 2019-01-25
• Last updated: 2019-03-22

Locations

1 site across 1 country: Switzerland