NCT03816592

Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass

Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypas

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 110 (actual)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Since the 1990s, the concept of anesthesia without morphine (OFA) has been developed. The principle is based on the fact that in a sleeping patient a sympathetic reaction marked by hemodynamic changes does not reflect a painful phenomenon, that a painful phenomenon in a sleeping patient is not memorized, that hormonal stress, sympathetic reaction and inflammatory reaction can be controlled by therapeutic classes other than a morphine agent. This therapeutic management would avoid the side effects associated with the use of morphine. In cardiac surgery, no studies have evaluated the effect of an OFA on morphine consumption and on a post-operative composite endpoint. Lidocaine was only studied in the context of cardioprotection and neuroprotection. Studies found a cardioprotective effect with a decrease in episodes of rhythmic disorders, and neuroprotective with a non-constant improvement in postoperative cognitive functions, but all these studies were performed during opioid anaesthesia (opioid agent use)/ The purpose of our study is to demonstrate that general anesthesia without opioid (OFA) is associated with a decrease in post-operative morphine consumption and an improvement in the patient's post-operative well-being (complications, confusion, vigilance, length of stay).

Conditions

• Opioid Free Anaesthesia
• Opioid Anaesthesia

Interventions

Type	Name	Description
PROCEDURE	Opioid free anaesthesia	patient anesthtesized with lidocaine, ketamine and dexamethasone
PROCEDURE	Opioid anaesthesia	patients anesthetized with sufentanil ketamine and dexamethasone

Timeline

• Start date: 2019-01-01
• Primary completion: 2019-03-31
• Completion: 2019-03-31
• First posted: 2019-01-25
• Last updated: 2026-02-04

Locations

1 site across 1 country: France