NCT03816033

Cryotherapy Versus Radiofrequency Catheter Ablation Research Program

Multi-catheter Cryotherapy Versus Radiofrequency Catheter Ablation for the Treatment of Standard and Resistant Arrhythmias

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: St. George's Hospital, London · Academic / Other
• Sex: All
• Age: 18 Years – 88 Years
• Healthy volunteers: Not accepted

Summary

A program of research has been set up at St. George's Hospital, London studyng the practicalities of catheter ablation. The current practice of catheter ablation is being studied for a range of arrhythmias including PAF, persistent AF, advanced persistent AF and resistant WPW.

Detailed description

The study design will be a separate randomised clinical trial for each of the arrhythmias studied. There will be 1:1 randomisation to either the cryotherapy protocol or RF protocol. Arrhythmia patients already under the care of this cardiac centre, who have already opted for catheter ablation treatment will be approached to ask if they will also be willing to participate in this longterm research program. The protocols for each different arrhythmia are in line with current practice and knowledge and utilising current technology. In the program, the investigators have 1 or 2 protocols that mildly differ from conventional use but have already passed through initial experience with publication on this- this is the multi-catheter cryocatheter approach. Acute procedural outcomes, short, medium and longterm success will be recorded for each patient, in addition to patient or participant experience and quality of life outcomes. The catheter ablation research program has passed through ethical panel review in London and has the potential to become a multi-centre study.

Conditions

• Atrial Fibrillation
• Atrial Tachycardia
• Wpw
• Ventricular Tachycardia

Interventions

Type	Name	Description
PROCEDURE	Cryotherapy	Catheter ablation treatment for the treatment of the studied arrhythmias
PROCEDURE	radiofrequency catheter ablation	Catheter ablation treatment for the treatment of the studied arrhythmias

Timeline

• Start date: 2018-06-01
• Primary completion: 2021-06-01
• Completion: 2023-06-01
• First posted: 2019-01-25
• Last updated: 2019-01-25

Locations

1 site across 1 country: United Kingdom