NCT03815981

Siderophore-profile in Allergic and Non-allergic Subjects

Linking Iron-deficiency With Allergy- the Role of Microbial Survival Components

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 74 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study aims to profile the siderophore-content in the human gut from allergic and non-allergic subjects and to assess their contribution in iron homeostasis.

Detailed description

Iron is an essential nutrient for the majority of commensal bacteria, which commonly secrete siderophores to liberate iron from their surroundings. In several studies, a misbalanced microbiota has been demonstrated in allergics suggesting that also their siderophore profile is severely attenuated. There are currently no data and very limited knowledge present on the composition of bacterial surviving factors in humans, or on their impact on the human immune system. As such, 1) the iron status, 2) the microbial biota composition and the 3) siderophore-profile in allergics and non-allergics will be assessed.

Conditions

• Allergy
• Healthy
• Allergic Sensitisation

Timeline

• Start date: 2018-12-12
• Primary completion: 2021-11-11
• Completion: 2021-12-12
• First posted: 2019-01-25
• Last updated: 2023-03-15

Locations

1 site across 1 country: Austria