NCT03811665

Stereotactic Body Radiation Therapy Versus Radiofrequency Ablation for Small Renal Masses

A Prospective Randomized Pilot Trial of Stereotactive Body Radiation Therapy Versus Radiofrequency Ablation for the Management of Small Renal Masses.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: St. Joseph's Healthcare Hamilton · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The execution of this study is pertinent to evaluating SBRT's short- and long-term efficacy and safety in the treatment of SRMs. This study will be the first to compare RFA and SBRT in the treatment of SRMs.

Conditions

• Small Renal Masses (SRM)

Interventions

Type	Name	Description
PROCEDURE	Radiofrequency Ablation	RFA probe will create an ablation zone of a 1.0 cm diameter beyond the maximum CT-measured tumor diameter. The generator will modulate power up to 150 W in reach average ablative temperature of 105oC. Tumors will be treated for two cycles of 8 minutes duration each upon reaching target temperatures.
RADIATION	Stereotactive body radiation therapy	The Gross Tumour Volume (GTV) is defined as the visible tumour seen on the planning CT simulation. No clinical target volume (CTV) for microscopic disease is necessary. The internal target volume (ITV) accounts for changes in tumour position due to respiration, and is assessed on 4DCT. The planning target volume (PTV) will be a standard 0.5 cm around the ITV.

Timeline

• Start date: 2019-10-01
• Primary completion: 2022-06-30
• Completion: 2022-12-30
• First posted: 2019-01-22
• Last updated: 2021-12-16

Locations

1 site across 1 country: Canada