NCT03811600

Exosomes Implication in PD1-PD-L1 Activation in OSAS

Exosomes Implication in PD1-PD-L1 Pathway Activation in Obstructive Sleep Apnea Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 90 (actual)
• Sponsor: University Hospital, Angers · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

An increased occurrence of cancer associated mortality has been described in patients with Obstructive Sleep Apnea Syndrome (OSAS). This association might be partially explained by an impaired cellular immune response that has been described in OSAS. Is has been suggested that OSAS impact immune cells by upregulation of the PD-1/PD-L1 pathway. Exosomes are small membrane vesicles released by numerous cells in the bloodstream. Exosomes have been shown to be implicated in cancer cells proliferation via a PD-1/PD-L1 pathway activation. This study will evaluate exosomal PD-1/PD-L1 expression in patients with OSAS as compared to controls and will further investigate their impact on immune cells function and proliferation capacities.

Conditions

• Sleep Apnea Syndromes, Obstructive
• Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	PD1/PD-L1 exosomal expression	exosomal PD1/PD-L1 expression

Timeline

• Start date: 2019-03-03
• Primary completion: 2020-10-14
• Completion: 2020-10-14
• First posted: 2019-01-22
• Last updated: 2023-02-10

Locations

1 site across 1 country: France