NCT03808961

Low Dose Niacin (Vitamin B3) for Parkinson's Disease

NAPS: Niacin for Parkinson's Disease

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: VA Office of Research and Development · Federal
• Sex: All
• Age: 35 Years
• Healthy volunteers: Not accepted

Summary

(1) To examine the blood, urine and spinal fluid of persons with Parkinson's to look for evidence of inflammation and; (2) whether 18 months of vitamin B3(niacin or niacinamide) supplementation may reduce the inflammation and/or improve PD motor and non-motor symptoms.

Detailed description

Number of people affected by Parkinson's disease is increasing each year. Vitamin B3 (Niacin/Niacinamide) supplement can be used to slow the progression of PD. Inflammation plays a central role in Parkinson's disease (PD) pathology as evidenced by the presence of microglia in the substantia nigra in post-mortem samples as well as activated microglia and cytokines in clinical and animal studies. The use of non-aspirin non-steroidal anti-inflammatory drugs was found to reduce the risk of PD. The investigators recently identified an anti-inflammatory receptor GPR109A that is upregulated in PD. Niacin has a high affinity for this receptor, suggesting that it (niacin) may play an important role in reducing inflammation in PD. The investigators also found that individuals with PD have a chronic niacin deficiency. In a three month trial at Augusta University (the investigators' affiliate) the investigators demonstrated that niacin was helpful for PD patients in reducing inflammatory macrophages and boosting the anti-inflammatory macrophages in blood. In this VA-funded study, the investigators will determine the effect of 18 months over-the-counter (OTC) niacin or niacinamide supplementation on inflammation (as assessed in the blood and spinal fluid) and severity of the PD symptoms.

Conditions

• Parkinson's Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Niacin	100mg tablets twice daily
DIETARY_SUPPLEMENT	Niacinamide	100mg tablets twice daily
OTHER	Placebo	Placebo tablet twice daily

Timeline

• Start date: 2020-01-01
• Primary completion: 2023-11-01
• Completion: 2023-11-01
• First posted: 2019-01-18
• Last updated: 2025-03-04
• Results posted: 2025-03-04

Locations

1 site across 1 country: United States