NCT03806504

High PEEP Application Following Pulmonary Thromboendarterectomy; Does it Have Any Impact on Outcome?

Prospective Randomized Trial of Impact of High PEEP Application Following Pulmonary Endarterectomy on Outcome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital · Other Government
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Investigation of the effect of intraoperative lung protection high PEEP maneuver on ischemic reperfusion injury in patients undergoing pulmonary endarterectomy.

Detailed description

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease characterized by progression of thromboembolism obstructing pulmonary arteries as an organized tissue. Pulmonary thromboendarterectomy (PTE) is a treatment option for chronic thromboembolic pulmonary disease. However, PTE is associated with specific postoperative complications, such as pulmonary edema and right ventricular failure due to reperfusion injury, with a significant mortality rate of 7% to 24%. Some strategies have been proposed to reduce lung injury after PTE, such as rectification maneuvers and high PEEP. The aim of this study was to investigate the effect of intraoperative lung protection high PEEP maneuver in patients undergoing pulmonary endarterectomy for ischemic reperfusion injury.

Conditions

• Reperfusion Injury After Pulmonary Thromboendarterektomy

Interventions

Type	Name	Description
OTHER	PEEP	performing 35 cm/H2O PEEP and 2-3 ml/kg tidal volume
OTHER	control group	performing 6 cm/H2O PEEP and 6-8 ml/kg tidal volume

Timeline

• Start date: 2019-01-01
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2019-01-16
• Last updated: 2021-05-07

Locations

1 site across 1 country: Turkey (Türkiye)