NCT03804957

Pneumothorax After CT-guided Lung Biopsy: Standard vs Autologous Blood Patching

The Incidence of Pneumothorax After CT-guided Lung Biopsy Performed With and Without Autologous Blood Patching: a Randomized Single-center Prospective Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Humanitas Clinical and Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The aim of this prospective, randomized study is to compare the rate of postoperative pneumothorax between standard CT-guided core needle biopsy (CNB) versus CNB followed by autologous blood patch injection (ABPI).

Detailed description

Pneumothorax is the most common complication of percutaneous lung biopsies. Reducing this risk is a goal of those who perform these procedures, particularly a reduction in large pneumothoraces requiring intervention (eg, pleural drainage) and hospitalization (Clayton et al. 2016). Recently, autologous blood patch injection (ABPI) inside the biopsy track has been suggested as an effective mean of sealing the punctured lung thus halting air loss and consequently pneumothorax (Graffy et al. 2017). The aim of this prospective, randomized study is to compare the rate of postoperative pneumothorax between standard CT-guided core needle biopsy (CNB) versus CNB followed by ABPI. In particular, the main objectives are to compare: 1. incidence of immediate pneumothorax 2. incidence of late pneumothorax (2 hrs) 3. incidence of chest tube placement 4. duration of the procedure

Conditions

• Pneumothorax
• Biopsy Wound

Interventions

Type	Name	Description
OTHER	Autologous blood patch injection (ABPI)	Autologous blood patch injection (ABPI) through a coaxial needle at the site of biopsy
OTHER	CT-guided core needle biopsy (CNB)	Standard 18g lung core biopsy

Timeline

• Start date: 2019-01-01
• Primary completion: 2019-12-01
• Completion: 2020-04-01
• First posted: 2019-01-15
• Last updated: 2019-01-15

Locations

1 site across 1 country: Italy