NCT03803618

Dengue Effectiveness Study in the Philippines

Effectiveness of the Tetravalent Dengue Vaccine, CYD-TDV (Dengvaxia®) in the Philippines

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,081 (actual)
• Sponsor: University of the Philippines · Academic / Other
• Sex: All
• Age: 9 Years – 14 Years
• Healthy volunteers: Accepted

Summary

This is an observational study that aims to determine the effectiveness of a tetravalent dengue vaccine (CYD-TDV) when given through a community-based immunization program against hospitalized and /or severe virologically confirmed dengue.

Detailed description

This is a matched case-control study. Cases will be children who are admitted with a clinical suspicion of dengue at the study hospitals and were eligible to have received the dengue vaccine during the mass immunization. The outcome of interest is hospitalized and/or severe virologically-confirmed dengue and the exposure is receipt of the dengue vaccine. Each case will be matched to two controls who were also eligible to have received the dengue vaccine and lives in the same area as the case. Cases and controls will be matched by age and sex.

Conditions

• Dengue
• Severe Dengue
• Virologically Confirmed Dengue

Timeline

• Start date: 2017-09-01
• Primary completion: 2022-11-30
• Completion: 2023-04-30
• First posted: 2019-01-14
• Last updated: 2023-05-17

Locations

4 sites across 1 country: Philippines