NCT03798925

mNGS for Detection of Pathogens for Pulmonary Infection

Microbiological Diagnostic Performance of Metagenomic Next-generation Sequencing for Pulmonary Infection in Clinical Settings

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Sir Run Run Shaw Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Pulmonary infections remain the leading causes of morbidity and mortality among patients worldwide. Pathogen identification is crucial yet difficult for the majority of the cases. Metagenomic Next-generation Sequencing provides a potential technology for rapid and untargeted pathogen detection for pulmonary infection. The study is designed observationally to investigate if mNGS is superior to traditional paradigm of serial tests in the aspect of diagnostic performance. Patients whose primary diagnosis is pulmonary infetion and bronchoalveolar lavage fluid can be obtained will be enrolled. Both mNGS and traditional paradigm of serial tests wil be performed.

Conditions

• Pulmonary Infection

Interventions

Type	Name	Description
OTHER	None Intervention	It is observational study

Timeline

• Start date: 2018-08-19
• Primary completion: 2019-02-01
• Completion: 2019-02-01
• First posted: 2019-01-10
• Last updated: 2019-01-10

Locations

1 site across 1 country: China