NCT03798886

Success Rate Natural Cycles Versus Modified Natural Cycles in Frozen Embryos

Comparison of Clinical Results of Frozen Embryo Transfer in Natural and Modified Natural Cycles

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Acibadem University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer

Detailed description

There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that: 1. The endometrium in stimulated cycles is not optimal for implantation 2. Pregnancy rates are increased following FET 3. Perinatal outcomes are less affected after FET 4. Preimplantation genetic screening We will follow only natural and modified natural cycles patients. Spontaneous ovulation will documented with hormonal and sonographic monitoring. Hormonal monitoring are including estradiol and luteinizing hormone (LH). Sonographic monitoring is including follicule diameter (16-20 mm). At modified natural cycles we will use hCG triggering for ovulation approximately 16-20 mm diameter. We will compare success rate between natural and modified natural cycles

Conditions

• Infertility, Female

Interventions

Type	Name	Description
OTHER	natural cycle	When follicle is ready for ovulation, we will use this injection by intra-dermal route
OTHER	modified natural cycle	we will use that drug in the natural modified transfer group after embryo transfer
OTHER	embryo transfer	we will do transfer when the endometrium is ready

Timeline

• Start date: 2018-01-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2019-01-10
• Last updated: 2019-03-13

Locations

1 site across 1 country: Turkey (Türkiye)