NCT03797937

Microbiome Benchmarking to Identify Perturbations in Multiple Sclerosis II

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 250 (actual)
• Sponsor: National MS Center Melsbroek · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The goal of this longitudinal study is to (1) explore the association between the gut microbiota and inflammatory disease activity in early onset multiple sclerosis, (2) investigate whether/how gut microbial composition vary when patients experience a relapse, and (3) to assess whether the gut microbiota shows increased similarities between affected pairs of first-degree relatives within the same family when compared with discordant pairs of first-degree relatives.

Detailed description

Using metagenomics, as well as clinical, immunological, and radiological observations, the investigators will investigate if active relapsing-remitting multiple sclerosis patients have a more pro-inflammatory gut microbiota signature than multiple sclerosis patients with less active disease and matched healthy controls. More specifically, the investigators will investigate whether temporal variability of the gut microbiota is related to inflammatory disease activity in multiple sclerosis, whether changes in the gut microbiota are predictive of future inflammatory disease activity in multiple sclerosis, and whether gut microbiota characteristics are predictive of the disease course after 2 years.

Conditions

• Multiple Sclerosis

Interventions

Type	Name	Description
OTHER	Magnetic resonance imaging (MRI)	MRI scanner

Timeline

• Start date: 2018-11-01
• Primary completion: 2021-11-01
• Completion: 2022-05-01
• First posted: 2019-01-09
• Last updated: 2022-05-11

Locations

2 sites across 1 country: Belgium