NCT03797469

Nutritional Supplements and Performance During Visual Field Testing (B3 Vitamin)

Nutritional Supplements and Performance During Visual Field Testing

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Columbia University · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study seeks to test whether these over-the-counter nutritional supplements have an impact on patients' performance during visual field testing.

Detailed description

Glaucoma is the leading cause of irreversible blindness worldwide. The most important test to detect progression is visual field testing. Visual field testing is the reference standard to measure visual function in glaucoma. It is called called standard automated perimetry (SAP). However, this test is very subjective, often unreliable, and variable. One of the main causes of unreliable tests is the lack of attentiveness or concentration during the test. Previous studies have shown that listening to Mozart or taking vitamin B12 can improve the reliability of this test. Recent studies have suggested that over-the-counter medications such as nicotinamide (vitamin B3) and pyruvate can also improve the performance during this test. This can ultimately reduce costs due to repeated testing and increase doctor's certainty when analyzing the results of this test.

Conditions

• Visual Field Defect, Peripheral
• Glaucoma, Open-Angle

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin B3	3 tablets of 1000 mg each will be administered orally.
DIETARY_SUPPLEMENT	Pyruvate	2 tablets of 1500 mg each will be administered orally.
DIETARY_SUPPLEMENT	Placebo	Tablets will look identical to the supplements and the number of tablets will equal the amount of supplements provided.

Timeline

• Start date: 2019-04-15
• Primary completion: 2020-12-31
• Completion: 2020-12-31
• First posted: 2019-01-09
• Last updated: 2021-11-11

Locations

1 site across 1 country: United States