NCT03794622

Autologous Bone Marrow Concentration for Femoral Shaft Fracture Union

The Effect of Autologous Bone Marrow Concentration on Femoral Shaft Fracture Union

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Pei-Yuan Lee, MD · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the effect of bone marrow concentration on union of femoral shaft fracture by comparing clinical and imaging outcomes between patients receiving Intramedullary nail fixation with intraoperative bone marrow concentration and those receiving Intramedullary nail fixation only.

Detailed description

Femoral shaft fracture is a common orthopaedic injury. Intramedullary nail is one of the standard treatments. Its primary goal is to develop an osseous bridge between adjacent motion segments to prevent motion, relieve pain, and facilitate bone union. Delayed union or nonunion is common in femoral shaft fracture. Risk factors include comminuted fracture, open fracture, smoking, diabetes and open reduction of fracture fixation. Mesenchymal stem cells are pluripotent cells that can differentiate into multiple mesenchymal tissues, including tenocytes, chondrocytes and osteoblasts, as well as being a source of multiple growth factors to establish an environment conducive to soft and hard tissue regeneration. As bone marrow concentration has high concentration of mesenchymal stem cells, some studies have shown that autologous bone marrow concentration can improve bone healing. Therefore, the goal of this study was to evaluate the effect of bone marrow concentration on union of femoral shaft fracture.

Conditions

• Bone Marrow
• Femoral Shaft Fracture

Interventions

Type	Name	Description
OTHER	intramedullary nail fixation with bone marrow concentration	intramedullary nail fixation with bone marrow concentration
OTHER	intramedullary nail fixation	intramedullary nail fixation only

Timeline

• Start date: 2017-06-14
• Primary completion: 2020-12-01
• Completion: 2020-12-01
• First posted: 2019-01-07
• Last updated: 2020-04-14

Locations

1 site across 1 country: Taiwan