NCT03793920

Effects of Prenatal Alcohol Exposure on Emotional and Cognitive Abilities in Adults

Behavioral Exploration of Cognitive and Emotional Alterations in Adult Individuals Exposed to Alcohol During the Prenatal Period

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 144 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Hypothesis: Individuals presenting with prenatal alcohol exposure (PEA) show emotional abilities deficits, and imbalance between the two systems involved in decision-making according to dual-process models, namely an under-activated reflective system (involved in deliberate behaviors) and an over-activated affective-automatic one (involved in impulsive behaviors). Primary objective: To explore performance (as a percentage of correct answers) in an emotional facial expression decoding task in PEA participants compared to controls without alcohol disorder.

Detailed description

Each participant will undergo 2 visits : First visit : * Checking inclusion and non-inclusion criteria * Note of information and consent form * Record of concomitant treatments and anamnestic elements * Alcohol, Tobacco, and Toxic Consumption * Urinary Toxicity Test for Control Groups * Laterality test (Hecaen, 1984) * Brief visual and auditory acuity test * Standardized psychiatric interview (Mini International Neuropsychiatric Interview - MINI) Second visit = Experimental testing * State-Trait Anxiety Inventory, Beck Depression Inventory, Inventory of Interpersonal Problems, Toronto Alexithymia Scale (TAS-20). * Participant installation and testing: 6 behavioral tasks on a computer (also used to collect responses, except for task 2, see details below) : Task 1 (MAIN): Test for recognition of facial emotions Task 2: 'Reading the Mind in the Eyes Test' (Decoding of complex emotional states) Task 3: Emotional evaluation of natural scenes Task 4: Target detection (measure of attentional bias towards alcohol-related stimuli) Task 5: Go / No-Go evaluating the interactions between inhibition processes and auto-affective system Task 6: "N-back" evaluating the interactions between working memory and automatic-affective system

Conditions

• Prenatal Alcohol Exposure

Interventions

Type	Name	Description
OTHER	Facial Emotion Test	All tasks will be delivered using a laptop and E-Prime 2 software (Psychology Software Tools, Inc., Pittsburgh), which will also be used to collect behavioral responses.

Timeline

• Start date: 2018-11-08
• Primary completion: 2022-11-11
• Completion: 2022-11-11
• First posted: 2019-01-04
• Last updated: 2022-10-03

Locations

2 sites across 1 country: France