NCT03790605

A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis

Evaluation of the Host Modulating Effects of 1% Curcumin Chips as an Adjunct to Non Surgical Mechanical Debridement in the Treatment of Periodontitis: A Randomised Controlled Clinical Trial

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: KLE Society's Institute of Dental Sciences · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The study will follow a parallel arm, randomised, double blinded, placebo controlled design. There will be two groups Group 1 = receiving 1% curcumin chips after routine scaling and root planing (n=20) Group 2 = receiving placebo chips after routine scaling and root planing (n=20) Clinical parameters: ( Baseline, 4 weeks, 12 weeks) Probing pocket depth, clinical attachment level, gingival index, plaque index Cytokine parameter ( Baseline, 4 weeks) Interleukin 1 beta in GCF Statistical analysis Repeated measures of ANOVA Paired t-tests

Conditions

• Periodontitis

Interventions

Type	Name	Description
DRUG	1 % curcumin chip	CURCUMIN CHIP: 4x5x0.5mm chip of 1% curcumin in biodegradable hydroxy propyl methyl cellulose vehicle
OTHER	Placebo chip	PLACEBO CHIP: 4x5x0.5mm chip (identical to test chip except for the active therapeutic ingredient) in biodegradable hydroxy propyl methyl cellulose vehicle
PROCEDURE	Scaling and root planing	Routine full mouth scaling and root planing within 48 hours will be performed at baseline prior to local placement of the chips

Timeline

• Start date: 2019-09-04
• Primary completion: 2020-09-01
• Completion: 2020-12-01
• First posted: 2018-12-31
• Last updated: 2019-12-13

Locations

1 site across 1 country: India