NCT03788187

Persistant Organics Pollutants in Breast Cancer.

Role of Persistant Organics Pollutants in the Metastatic Potential of Malignant Breast Tumor.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: European Georges Pompidou Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Persistant Organics Pollutants (POP) accumulate in the adipose tissue (AT) and could modulate tumor progression as part of the microenvironment. The investigators tested the hypothesis that POPs exposure may be associated with breast cancer metastasis analyzing the concentrations of 46 POPs in both adipose tissue and serum samples from breast tumor patients (benign, malignant with and without lymph node metastasis)

Detailed description

The investigators set up a longitudinal prospective monocentric cohort study in the gynecologic-oncologic surgery department of European Hospital Georges-Pompidou, with patients undergoing partial or total mastectomies, lymph node biopsies or axillary lymph node removal and sampling of the adipocytic tumour microenvironment to measure POPs using gas chromatography coupled to high-resolution mass spectrometry. The objective is to analyze the concentrations of 46 POPs including polychlorinated dibenzo(p)dioxins and furans (PCDD/Fs), polychlorinated biphenyls (PCBs), polybromodiphenyl ethers (PBDEs) and polybromobiphenyls (PBBs) in both adipose tissue (AT) and serum samples from breast tumor patients (benign, malignant with and without lymph node metastasis).

Conditions

• Breast Cancer
• Persistant Organic Pollutants
• Lymph Node Metastases

Interventions

Type	Name	Description
OTHER	Blood test sample
OTHER	Peritumoral adipose tissue sample

Timeline

• Start date: 2013-08-01
• Primary completion: 2013-12-27
• Completion: 2017-09-15
• First posted: 2018-12-27
• Last updated: 2018-12-27