NCT03786263

CHILDNEPH The Canadian Childhood Nephrotic Syndrome Study

The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) Project

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: University of Calgary · Academic / Other
• Sex: All
• Age: 1 Year – 17 Years
• Healthy volunteers: Not accepted

Summary

CHILDNEPH is a pan-Canadian project to observe clinical care for children with nephrotic syndrome. Previous studies have indicated that there is wide practice variation in how health care providers treat this remitting and relapsing disease of childhood. The disease mechanism is not yet understood, and long-term use of steroids can affect children's health. This study involves assessment of routine clinical care and establishing a long-term patient registry for children with nephrotic syndrome.

Detailed description

CHILDNEPH is an ongoing prospective longitudinal study of children with incident and prevalent nephrotic syndrome. Children are recruited from 12 centres across Canada and followed for at least 30 months. The project starting in August of 2013 with the goal of following 400 patients. Data is collected at enrollment, beginning and end of each relapse, semi-annual visits and end of study. Detailed prescription data is collected regarding glucocorticoids and all second line agents. All relapses are recorded with time to urinary remission of proteinuria. The investigators are moving towards registry based trials to determine optimal treatment protocols for nephrotic syndrome with an overall goal to minimize glucocorticoid exposure, a patient priority.

Conditions

• Nephrotic Syndrome in Children
• Nephrotic Syndrome, Minimal Change
• Nephrotic Syndrome，Idiopathic

Timeline

• Start date: 2014-08-03
• Primary completion: 2020-06-30
• Completion: 2022-03-31
• First posted: 2018-12-26
• Last updated: 2019-05-06

Locations

12 sites across 1 country: Canada