NCT03785509

The Compliance of DAPT and Statins on Clinical Outcomes in Percutaneous Coronary Intervention Patients

The Effect of Persistence and Compliance of Antiplatelet and Dyslipidemia Agents on Cardiovascular Outcomes in Real World Patients Undergoing Percutaneous Coronary Intervention

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 47,291 (actual)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: —
• Age: —
• Healthy volunteers: —

Summary

A nationwide retrospective cohort study. To investigate the real world medication compliance and the relation with clinical outcomes. The persistence and compliance to dual anti-platelet therapy(DAPT) and dyslipidemia agents are important for the patients undergoing percutaneous coronary intervention. But, the discontinuation and compliance rate are unknown in the real world setting.

Detailed description

A nationwide retrospective cohort study. The persistence and compliance to dual anti-platelet therapy(DAPT) and dyslipidemia agents are important for the patients undergoing percutaneous coronary intervention. The discontinuation and uncompliance may increase a risk. But, the discontinuation and compliance rate are not well known in the real world patients undergoing bare metal stents(BMS) and drug eluting stents(DES) insertion. To investigate the real world medication compliance and the relation with clinical outcomes, administrative claim data was extracted from the Korean National Healthcare Insurance(KNHI) database. All Korean patient date undergoing PCI from January 1, 2011 to December 2011 is extracted. 5 year clinical outcomes are investigated. Primary outcomes are the MACE including all-cause death, revascularization, critically ill status, and stroke) classified by the medication compliance. Medication complinace is measured by proportion of days covered(PDC) Secondary outcomes are the patterns of medication persistence and its outcomes to understand critical points.

Conditions

• Platelet Aggregation Inhibitors
• Hydroxymethylglutaryl-coa Reductase Inhibitors
• Compliance, Medication
• Adherence, Medication
• Persistence, Medication
• Percutaneous Coronary Intervention

Interventions

Type	Name	Description
DRUG	DAPT, Statin	Compliance of DATP, Compliance of Statin, Drug Eluting Stent, Bare Metal Stent

Timeline

• Start date: 2017-04-06
• Primary completion: 2018-02-06
• Completion: 2018-11-30
• First posted: 2018-12-24
• Last updated: 2018-12-24

Locations

1 site across 1 country: South Korea