NCT03785470

Vascular and Metabolic Consequences of Adopting a Westernized Lifestyle

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: University of Missouri-Columbia · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if short-term adoption of a Westernized lifestyle characterized by physical inactivity and increased consumption of fructose will result in metabolic and vascular dysfunction. Healthy individuals aged 18-45 years old will undergo an acute period of physical inactivity (10 days) coupled with increased fructose consumption. Augmented fructose consumption will be achieved via commercially available soda beverages which are high in fructose. Vascular and metabolic function measures will be performed before and after the 10-day intervention.

Detailed description

Men and women who regularly engage in \>10,000 steps per day, age 18-45 years, body mass index \< 30 kg/m2, and with no history of chronic disease will be recruited. Subjects who are eligible will undergo an acute period of physical inactivity (10 days) coupled with increased fructose consumption (6 cans/day). Physical activity levels will be assessed via a pedometer to quantify if individuals achieve \<5000 steps/day. Vascular and metabolic function measures will be performed before and after the 10-day intervention.

Conditions

• Vascular Diseases

Interventions

Type	Name	Description
OTHER	Fructose and physical inactivity	Subjects will drink 6 cans of regular sodas daily (divided throughout the day) and will decreased physical activity to less than 5000 steps daily for 10 days.

Timeline

• Start date: 2018-11-30
• Primary completion: 2022-08-01
• Completion: 2022-08-16
• First posted: 2018-12-24
• Last updated: 2022-08-17

Locations

1 site across 1 country: United States