NCT03783208

Intrauterine G-CSF Administration in RIF

Intrauterine G-CSF Administration in Recurrent Implantation Failure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 157 (actual)
• Sponsor: Gurgan Clinic · Network
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Aim of this study is to investigate the effects of intrauterine G-CSF on endometrial thickness, clinical pregnancy rate and live birth rate in a recurrent implantation failure (RIF) group

Detailed description

This study was designed as a prospective randomized controlled trial with the involvement of 200 RIF group patients.The procedure will perform by administering 30 mIU of Leucostim®(Filgrastim \[G-CSF\] 30mIU/mL; DEM Medical, Dong-A; South Korea) through slow infusion into the endometrial cavity using a soft embryo transfer catheter. Normal saline of 1 mL will be infused into the endometrial cavity in the same way in the control group. The standard ICSI procedure will use for all patients, and fresh cycle embryos will be transferred on the third or fifth day.

Conditions

• Infertility

Interventions

Type	Name	Description
DRUG	G-CSF	Slow infusion of G-CSF into the endometrial cavity using a soft embryo transfer catheter.
OTHER	Saline	Slow infusion of saline into the endometrial cavity using a soft embryo transfer catheter.

Timeline

• Start date: 2018-11-01
• Primary completion: 2018-12-20
• Completion: 2018-12-20
• First posted: 2018-12-20
• Last updated: 2018-12-24

Locations

1 site across 1 country: Turkey (Türkiye)