NCT03780725

This Study Tests How BI 754111 is Distributed in Patients With Advanced Non-small Cell Lung Cancer or Patients With Head and Neck Cancer Who Are Treated With BI 754091

An Open Label Phase I PET Imaging Study to Investigate the Bio-distribution and Tumor Uptake of [89Zr]Zr-BI 754111 in Patients With Advanced Non-small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma Treated With BI 754111 in Combination With BI 754091

• Status: Terminated
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Boehringer Ingelheim · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The main objective of this study is to determine the biodistribution and intra-tumor accumulation of \[89Zr\]Zr-BI 754111 at baseline and its change upon treatment

Conditions

• Carcinoma, Non-Small-Cell Lung
• Head and Neck Neoplasms

Interventions

Type	Name	Description
DRUG	BI 754111	Solution for infusion
DRUG	[89Zr]Zr-BI 754111	Solution for infusion
DRUG	BI 754091	Solution for infusion

Timeline

• Start date: 2019-01-22
• Primary completion: 2020-02-19
• Completion: 2020-12-08
• First posted: 2018-12-19
• Last updated: 2026-01-13
• Results posted: 2026-01-13

Locations

1 site across 1 country: Netherlands