NCT03778983

Cognitive Development After Pediatric Liver Transplantation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 130 (actual)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: All
• Age: 2 Years – 7 Years
• Healthy volunteers: —

Summary

The purpose of this study is to investigate the cognitive performance after pediatric live transplantation.

Detailed description

During the last 20 years, survival rates after pediatric liver transplantation (Ltx) have increased steadily. Today, pediatric Ltx is a well-established treatment for a variety of liver diseases in their final stage. Even in relative indications (i.e. certain metabolic diseases), liver transplantation is a promising treatment option that actually is becoming increasingly important in clinical practice . Importantly, childhood cognitive ability is highly predictive for educational achievement and later occupational outcomes as well as health behavior . Current research indicates that liver transplanted children are at higher risk for developing cognitive deficits compared to the age-matched normal population . The aim of present study is to evaluate the cognitive development after pediatric liver transplantation. The investigators expect to understand of the association between cognitive deficits and certain disease-related variables, which may be contribute to optimizing clinical care of these patients.

Conditions

• Cognitive Development After Pediatric Live Transplantation

Timeline

• Start date: 2018-12-20
• Primary completion: 2019-05-30
• Completion: 2019-05-30
• First posted: 2018-12-19
• Last updated: 2022-04-06

Locations

1 site across 1 country: China