NCT03778944

Enhancing Renal Graft Function During Donor Anesthesia

Renal Graft Functional Enhancement During Donor Anesthesia: A Comparative Study of 3 Modalities

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Nazmy Edward Seif · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess \& compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.

Conditions

• Renal Failure Chronic
• Transplant;Failure,Kidney
• Anesthesia

Interventions

Type	Name	Description
PROCEDURE	Mannitol infusion	Infusion of Mannitol 20% at a dose of 0.5 mg/kg to the renal graft donor after induction of anesthesia over 15 minutes.
PROCEDURE	Dopamine infusion	Infusion of Dopamine at a dose of 4 microg/kg/min to the renal graft donor after induction of anesthesia till ligation of the renal artery.
PROCEDURE	Adequate hydration	Infusion of Ringer Acetate at a rate of 15 ml/kg/hr to the renal graft donor after induction of anesthesia till ligation of the renal artery.

Timeline

• Start date: 2018-12-20
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2018-12-19
• Last updated: 2026-01-12

Locations

1 site across 1 country: Egypt