Trials / Completed
CompletedNCT03778736
Using Cumulase for Denudation of Cycles With ≤ 8 Cumulus-oocytes Complexes
Can Cumulase Reduce the Shear Stress During Denudation for ICSI Cycles of ≤ 8 Cumulus-oocytes Complexes
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 586 (actual)
- Sponsor
- Ibn Sina Hospital · Other Government
- Sex
- Female
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Not accepted
Summary
The cumulus-corona-oocyte complex (COCs) surrounds each oocyte and must be removed prior to intracytoplasmic sperm injection (ICSI). This is traditionally achieved with a bovine-derived hyaluronidase followed by mechanical denudation through pipetting. A human recombinant hyaluronidase (Cumulase) has been developed to circumvent the problems and concerns associated with the animal origin and lack of purity of the bovine-derived form of the enzyme. whether cumulase offers a higher chance for success after ICSI for women with 8 COCs or lower remains an open question.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Cumulase denudation | Testing the effect of cumulase for women with poor oocyte yield due to poor ovarian reserve |
Timeline
- Start date
- 2018-01-27
- Primary completion
- 2019-08-01
- Completion
- 2019-08-05
- First posted
- 2018-12-19
- Last updated
- 2019-08-07
Locations
3 sites across 1 country: Egypt
Source: ClinicalTrials.gov record NCT03778736. Inclusion in this directory is not an endorsement.