NCT03774043

Timing and Dosage of Acute Intermittent Hypoxia in Persons With SCI

Timing and Dosage Parameters of Acute Intermittent Hypoxia in Individuals With Spinal Cord Injury.

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Shirley Ryan AbilityLab · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study will utilize short duration and mild levels of reduced oxygen (hypoxia) to induce spinal plasticity while evaluating the appropriate timing schedule for this intervention, as well as, the effects of superimposing sessions of a therapy, in individuals with chronic incomplete SCI. Our aim is to establish the time-course of outcome improvement and decay following a single session or multiple sessions of AIH therapy.

Conditions

• Spinal Cord Injuries

Interventions

Type	Name	Description
OTHER	Acute Intermittent Hypoxia	Patients will breath 9%-11% oxigen for 1.5 minutes interspersed with 1.5 minutes of 21% oxigen (normoxia), 15 times for a total of 45 minutes.
OTHER	Sham Acute Intermittent Hypoxia	Patients will breath 21% oxigen for 1.5 minutes interspersed with 1.5 minutes of room air, 15 times for a total of 45 minutes.

Timeline

• Start date: 2016-05-01
• Primary completion: 2020-03-01
• Completion: 2020-07-01
• First posted: 2018-12-12
• Last updated: 2020-02-19

Locations

1 site across 1 country: United States