NCT03773900

Characterization of Gut Microbiota Composition and Activity After a Daily Supplementation of 4.5 g/Day of ChitinGlucan Fibre During 3 Weeks in At-cardiometabolic Risk Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to demonstrate the beneficial effects on gut microbiota composition and activity of the diary intake of insoluble fiber (extract from Aspergillus Niger) for three weeks. The first studies about the fiber have shown a favorable gut microbiota modulation and an improvement of metabolic parameters like LDL cholesterol. In addition to fecal measurements, several biomarkers of colic fermentation will be assessed: expired gases, PolyUnsaturated Fatty Acid, Short Chain Fatty Acid (SCFA) after a rich-fiber breakfast (= 15 grams) and a nutritional challenge test at lunch. The gastrointestinal tolerance of fiber intake and the intestinal transit modification will be also followed during all the study.

Conditions

• Cardiometabolic Risk
• Abdominal Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Kiotransine (chitin-glucan from aspergillus niger)	The volunteers will take three times a day one bag of powder containing 1.5g of chitin-glucan fiber during three weeks. The powder will be diluted in water.
DIETARY_SUPPLEMENT	Placebo	The volunteers will take three times a day one bag of powder containing placebo during three weeks. The powder will be diluted in water.

Timeline

• Start date: 2018-11-07
• Primary completion: 2019-06-06
• Completion: 2019-06-06
• First posted: 2018-12-12
• Last updated: 2025-09-15

Locations

1 site across 1 country: France