Trials / Completed
CompletedNCT03771326
KP-10 and Insulin Secretion in Men
Preliminary Evidence Suggesting That Acute Administration of KP-10 Induces Insulin Secretion in Normal Weight But Not in Obese Men
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 14 (actual)
- Sponsor
- Quaid-e-Azam University · Academic / Other
- Sex
- Male
- Age
- 20 Years – 45 Years
- Healthy volunteers
- Accepted
Summary
Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear. The present study was designed to investigate the role of KP-10 on insulin secretion in adult healthy and obese men with insulin resistance. The aim of selection of obese persons for the present study was to investigate the effect of acute KP-10 administration in a metabolically challenged condition where the pancreatic beta cells are already highly activated. The long-term objective of this study was to understand the physiological role of kisspeptin signalling in the regulation of insulin secretion in human health and disease.
Conditions
- Kisspeptin Action on Insulin in Healthy Normal Men
- Kisspeptin Action on Insulin in Obese Diabetic Men
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Kisspeptin-10 | Kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany) |
Timeline
- Start date
- 2013-10-29
- Primary completion
- 2013-11-04
- Completion
- 2014-01-10
- First posted
- 2018-12-11
- Last updated
- 2018-12-12
Source: ClinicalTrials.gov record NCT03771326. Inclusion in this directory is not an endorsement.