NCT03769922

Postoperative Progression of the Disease Following Extensive Versus Limited Mesenteric Excision for Crohn's Disease

The MESOCOLIC Trial: Mesenteric Excision Surgery or Conservative Limited Resection in Crohn's Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 116 (estimated)
• Sponsor: Jinling Hospital, China · Academic / Other
• Sex: All
• Age: 16 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The study evaluates whether there is a reduction in the rate of postoperative progression of the disease following extensive mesenteric excision (EME), when compared to that of limited mesenteric excision (LME), in patients undergoing ileocolic resection for Crohn's disease. Half of participants will receive EME, while the other half will receive LME.

Detailed description

EME and LME are the two surgical procedures which are commonly used in the treatment of Crohn's disease. However, the areas of the mesenteric tissue resected are different. EME means that the mesentery is resected avoiding the root region, i.e. 1 cm from the root of ileocolic artery and vein. LME represents that the mesentery is retained, i.e. "Close shave" or 3 cm from the border of bowel (using whatever approach - clips, or haemostatic vessel sealing device).

Conditions

• Postoperative Surgical Recurrence

Interventions

Type	Name	Description
PROCEDURE	Extensive mesenteric resection	The mesentery is resected avoiding the root region.
PROCEDURE	Limited mesenteric excision	The mesentery is retained.

Timeline

• Start date: 2019-02-18
• Primary completion: 2024-01-01
• Completion: 2025-01-01
• First posted: 2018-12-10
• Last updated: 2019-02-27

Locations

1 site across 1 country: China