NCT03769818

Role of Dexamethasone for Erector Spinae Plane Block in Patients Undergoing Total Abdominal Hysterectomy

Role of Adjuvant Dexamethasone for Erector Spinae Plane Block for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy: A Randomized, Double-blind Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Aswan University Hospital · Academic / Other
• Sex: Female
• Age: 30 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The aim to study the efficacy of bupivacaine 0.25% with dexamethasone and that of bupivacaine 0.25% alone for erector spinae plane block for postoperative analgesia in patients undergoing total abdominal hysterectomy Group 1: bupivacaine 0.25% + dexamethasone 8 mg * Group 2: bupivacaine 0.25% * Group3: control group A prospective Randomized Interventional double-blind study.

Detailed description

Optimal dynamic analgesia is recognized as the key to enhanced recovery following open abdominal surgery. In the last decade, there has been a significant shift away from thoracic epidural analgesia (TEA) that has been long considered as the gold standard. Various techniques have tried to replicate the analgesic efficacy of TEA. They include transversus abdominis plane analgesia (TAP), rectus sheath analgesia (RS), wound infusion analgesia (WI) and trans muscular quadratus lumborum analgesia. However, each of these techniques has specific limitations that prevent them from being the analgesic technique of choice for all open abdominal surgeries. Chin et al first described the erector spinae plane (ESP) block for providing analgesia following ventral hernia repair. The unique feature of the ultrasound-guided truncal blocks is that in all of these techniques, in contrast to peripheral nerve blocks, no nerve or plexus needs to be identified: Local anesthesia (LA) is injected in a particular muscle plane, in which the injectate spreads and reaches the intended nerves. This simple mechanism has made delivery of nerve blocks easy and versatile.

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
DRUG	bupivacaine	Bilateral TAP block with 20 ml of 0.25% bupivacaine
DRUG	dexamethasone	Bilateral TAP block with 4 mg/kg dexamethasone diluted with isotonic saline.
DRUG	placebo to dexamethasone	Bilateral TAP block with placebo to dexamethasone.
DRUG	placebo to bupivacaine	Bilateral TAP block with placebo to bupivacaine.

Timeline

• Start date: 2019-01-01
• Primary completion: 2020-03-30
• Completion: 2020-08-01
• First posted: 2018-12-10
• Last updated: 2020-08-05

Locations

1 site across 1 country: Egypt