NCT03769376

Histologic Comparison of Healing After Tooth Extraction With Ridge Preservation Using Two Different Xenografts

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to compare the speed of bone healing of the two most commonly used xenografts on the market, Bio-Oss® and Salvin-Oss® using a tooth extraction ridge preservation model in participants scheduled for tooth extraction and subsequent receipt of a dental implant. Researchers hypothesize that there will be additional vital bone at 16-20 weeks with Salvin-Oss®.

Detailed description

This study focuses on xenografts to preserve alveolar bone after tooth extraction prior to placement of a dental implant. Extraction sites that are not grafted for ridge preservation may lose up to 50 percent of their ridge width the first year after extraction. Xenografts are one of several products on the market used to maintain ridge width after tooth extraction. This study aims to compare the two most commonly used, FDA-approved xenografts on the market, Bio-Oss® and Salvin-Oss, in the preservation of alveolar bone after extraction of non-molar teeth. The primary objective of this study is to histologically evaluate and compare the percentage of new bone formation in healing extraction sockets of non-molar teeth grafted with Bio-Oss® versus Salvin-Oss®. The secondary aim is to observe clinical changes in ridge height and ridge width after grafting with these two materials.

Conditions

• Partial Edentulism

Interventions

Type	Name	Description
DEVICE	Bio-Oss®	Bio-Oss® xenograft bone material will be placed into the socket following tooth extraction.
DEVICE	Salvin-Oss®	Salvin-Oss® xenograft bone material will be placed into the socket following tooth extraction.

Timeline

• Start date: 2019-05-22
• Primary completion: 2021-03-15
• Completion: 2021-03-15
• First posted: 2018-12-07
• Last updated: 2021-12-15
• Results posted: 2021-12-15

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study