NCT03767920

Role of Dexamethasone in Transversus Abdominis Plane Block After Cesarean Section

Role of Co-administered Dexamethasone in Transversus Abdominis Plane Block After Cesarean Section: A Randomized, Double-blind Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Aswan University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Our aim to study the efficacy of bupivacaine 0.25% with dexamethasone and that of bupivacaine 0.25% alone in transversus abdominis plane (TAP) block for postoperative analgesia in patients undergoing an elective Caesarean section. * Group 1: bupivacaine 0.25% + dexamethasone 8 mg * Group 2: bupivacaine 0.25% A prospective Randomized Interventional double-blind study.

Detailed description

The pain and discomfort following cesarean delivery are mostly due to the abdominal wall incision and dissection of muscles; it delays early ambulation and breastfeeding. This can lead to postoperative complications such as thromboembolic disorders. So, providing an effective and safe postoperative analgesic method seems to be mandatory. Opioid analgesia remains the most effective means of relieving pain in a wide variety of conditions; however, it may cause adverse effects such as nausea, vomiting, pruritus, urinary retention, and respiratory depression. As the analgesia and the side effects of opioids are dose-dependent, a multimodal approach may enhance analgesia, which in turn would decrease the side effects . Mc Donnell and colleagues have reported that a transversus abdominis plane (TAP) block can decrease the postoperative pain following abdominal surgery. The landmarks of this block were first described in 2001 by Rafi. The TAP block has been performed for postoperative analgesic control in patients undergoing radical prostatectomy, hysterectomy, cesarean delivery under spinal anesthesia, and laparoscopic surgery.

Conditions

• Cesarean Section

Interventions

Type	Name	Description
DRUG	bupivacaine	TAP block with 20 ml of 0.25% bupivacaine bilaterally
DRUG	dexamethasone	TAP block with 4 mg dexamethasone bilaterally
DRUG	placebo to dexamethasone	TAP block with 4 mg placebo to dexamethasone bilaterally

Timeline

• Start date: 2019-01-01
• Primary completion: 2020-03-30
• Completion: 2020-08-01
• First posted: 2018-12-07
• Last updated: 2020-08-05

Locations

1 site across 1 country: Egypt