NCT03767062

Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse Headaches

Comparison of Effects of Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse Headaches: A Randomised Parallel Group Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Ataturk University · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

Purpose: In this study, the investigators compared the effectiveness of peripheral nerve block (greater occipital nerve block with supratrochlear nerve block) versus topiramate as detoxification therapies in chronic migraine patients with medication overuse headache. Methods: At least ninety chronic migraine patients with medication overuse headache are aimed to include in this study. Patients will be divided into the two groups. The first group will receive topiramate (n=45, estimated) and the second group will receive nerve block (n=45, estimated) as detoxification therapy. Patients' records regarding the visual analog scale (VAS) scores and headache frequencies are aimed to be collected before and after the therapy. Comparisons regarding VAS scores, headache frequencies, 50% responder rates and 75% responder rates will be performed in between topiramate and nerve block groups.

Conditions

• Medication Overuse Headache
• Chronic Migraine, Headache

Interventions

Type	Name	Description
DRUG	Topamax	An antiepileptic agent used for migraine prophylaxis.
PROCEDURE	Greater Occipital Nerve Block + Supratrochlear Nerve Block	An injection to paralyze the occipital and supratrochlear nerves.

Timeline

• Start date: 2019-03-01
• Primary completion: 2019-03-31
• Completion: 2019-03-31
• First posted: 2018-12-06
• Last updated: 2020-01-22
• Results posted: 2020-01-22

Locations

1 site across 1 country: Turkey (Türkiye)